ESCRT-III Dysfunction Causes Autophagosome Accumulation and Neurodegeneration

  title={ESCRT-III Dysfunction Causes Autophagosome Accumulation and Neurodegeneration},
  author={Jin-A. Lee and Anne Beigneux and Syed Tariq Ahmad and Stephen G. Young and Fen-Biao Gao},
  journal={Current Biology},
Defects in the endosomal-lysosomal pathway have been implicated in a number of neurodegenerative disorders. A key step in the endocytic regulation of transmembrane proteins occurs in a subset of late-endosomal compartments known as multivesicular bodies (MVBs), whose formation is controlled by endosomal sorting complex required for transport (ESCRT). The roles of ESCRT in dendritic maintenance and neurodegeneration remain unknown. Here, we show that mSnf7-2, a key component of ESCRT-III, is… CONTINUE READING
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