ESAT-6/CFP10 Skin Test Predicts Disease in M. tuberculosis-Infected Guinea Pigs

@article{Weldingh2008ESAT6CFP10ST,
  title={ESAT-6/CFP10 Skin Test Predicts Disease in M. tuberculosis-Infected Guinea Pigs},
  author={Karin Nana Weldingh and Peter Andersen},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={2785 - 7}
}
BACKGROUND Targeted preventive chemotherapy of individuals with progressive subclinical (incipient) disease before it becomes contagious would break the chain of tuberculosis transmission in high endemic regions. We have studied the ability of a skin test response to ESAT-6 and CFP10 (E6/C10) to predict later development of tuberculosis disease in the guinea pig model. METHODS AND FINDINGS Guinea pigs, either vaccinated with BCG or unvaccinated, were infected with a low dose of Mycobacterium… CONTINUE READING

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