ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

@article{Aladjem1998ESCD,
  title={ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage},
  author={Mirit I. Aladjem and Benjamin T. Spike and Luo Wei Rodewald and Thomas J Hope and Martina Klemm and Rudolf Jaenisch and Geoffrey M. Wahl},
  journal={Current Biology},
  year={1998},
  volume={8},
  pages={145-155}
}
BACKGROUND Embryonic stem (ES) cells can contribute precursors to all adult cell lineages. Consequently, damage to ES cell genomes may cause serious developmental malfunctions. In somatic cells, cell-cycle checkpoints limit DNA damage by preventing DNA replication under conditions that may produce chromosomal aberrations. The tumor suppressor p53 is involved in such checkpoint controls and is also required to avoid a high rate of embryonic malformations. We characterized the cell-cycle and DNA… CONTINUE READING
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