ERp29, an endoplasmic reticulum secretion factor is involved in the growth of breast tumor xenografts.

@article{Mkrtchian2008ERp29AE,
  title={ERp29, an endoplasmic reticulum secretion factor is involved in the growth of breast tumor xenografts.},
  author={Souren Mkrtchian and Mikhail Baryshev and Ernest Sargsyan and Ioulia Chatzistamou and A. Volakaki and Nick Chaviaras and Agatha Pafiti and Aggeliki Triantafyllou and Hippokratis Kiaris},
  journal={Molecular carcinogenesis},
  year={2008},
  volume={47 11},
  pages={
          886-92
        }
}
Cancer cells are committed to an actively secretory state that facilitates communication with their microenvironment. We have addressed the role of ERp29, a novel endoplasmic reticulum secretion factor in mammary carcinogenesis using MCF-7 human breast cancer cells as a model. Xenografts originating from cells stably transfected with dominant-negative form of ERp29 were smaller and better differentiated than those derived from cells overexpressing wild-type ERp29. Similar effects were observed… CONTINUE READING
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