ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins.

  title={ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins.},
  author={Barbara Knoblach and Bernd O Keller and Jody Groenendyk and Sandi Aldred and Jing Zheng and Bernard D Lemire and Liang Li and Marek Michalak},
  journal={Molecular & cellular proteomics : MCP},
  volume={2 10},
Using a proteomic analysis of the luminal environment of the endoplasmic reticulum (ER), we have identified 141 proteins, of which 6 were previously unknown. Two newly discovered ER luminal proteins, designated ERp19 and ERp46, are related to protein disulphide isomerase. Western and Northern blot analyses revealed that both ERp19 and ERp46 and their respective mRNAs are highly expressed in the liver as compared with other tissues. Both proteins were enriched in purified liver ER vesicles and… CONTINUE READING

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