ERNE-BS5: aligning BS-treated sequences by multiple hits on a 5-letters alphabet

  title={ERNE-BS5: aligning BS-treated sequences by multiple hits on a 5-letters alphabet},
  author={N. Prezza and C. D. Fabbro and F. Vezzi and E. D. Paoli and A. Policriti},
  booktitle={BCB '12},
  • N. Prezza, C. D. Fabbro, +2 authors A. Policriti
  • Published in BCB '12 2012
  • Computer Science
  • Cytosine methylation is a DNA modification that has great impact on the regulation of gene expression and important implications for the biology and health of several living beings, including humans. Bisulfite conversion followed by next generation sequencing (BS-seq) of DNA is the gold standard technique used to detect DNA methylation at single-base resolution on a genome scale through the identification of 5-methylcytosine (5-mC). However, by converting unmethylated cytosines into thymines… CONTINUE READING
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