ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association.


RNAi screening for kinases regulating the functional organization of the early secretory pathway in Drosophila S2 cells has identified the atypical Mitotic-Associated Protein Kinase (MAPK) Extracellularly regulated kinase 7 (ERK7) as a new modulator. We found that ERK7 negatively regulates secretion in response to serum and amino-acid starvation, in both… (More)
DOI: 10.1038/emboj.2011.253