ERK5 negatively regulates tobacco smoke-induced pulmonary epithelial–mesenchymal transition

@inproceedings{Liang2015ERK5NR,
  title={ERK5 negatively regulates tobacco smoke-induced pulmonary epithelial–mesenchymal transition},
  author={Zhaofeng Liang and Wei Xie and Rui Wu and Hao Geng and Li Zhao and Chunfeng Xie and Xiaoting Li and Cong Fa Huang and Jianyun Zhu and Mingming Zhu and Weiwei Zhu and Jieshu Wu and Shanshan Geng and Caiyun Zhong},
  booktitle={Oncotarget},
  year={2015}
}
As the primary cause of lung cancer, tobacco smoke (TS) promotes the initiation and progression of lung tumorigenesis. Epithelial-mesenchymal transition (EMT) is a crucial process involved in cell malignant transformation. The role of ERK5, the lesser studied member of MAPKs family, in regulating TS-triggered pulmonary EMT has not been investigated. Normal human bronchial epithelial cells and BALB/c mice were used as in vitro and in vivo TS exposure models. Exposure of normal human bronchial… CONTINUE READING

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