ERK5 activation inhibits inflammatory responses via peroxisome proliferator-activated receptor delta (PPARdelta) stimulation.

@article{Woo2006ERK5AI,
  title={ERK5 activation inhibits inflammatory responses via peroxisome proliferator-activated receptor delta (PPARdelta) stimulation.},
  author={C F Woo and Michael P Massett and Tetsuro Shishido and Seigo Itoh and Bo Ding and Carolyn McClain and Wenyi Che and Sreesatya Raju Vulapalli and Chen Yan and Jun-ichi Abe},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 43},
  pages={32164-74}
}
Peroxisome proliferator-activated receptors (PPAR) decrease the production of cytokine and inducible nitric-oxide synthase (iNOS) expression, which are associated with aging-related inflammation and insulin resistance. Recently, the involvement of the induction of heme oxygenase-1 (HO-1) in regulating inflammation has been suggested, but the exact mechanisms for reducing inflammation by HO-1 remains unclear. We found that overexpression of HO-1 and [Ru(CO)(3)Cl(2)](2), a carbon monoxide (CO… CONTINUE READING
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