ERK2 is required for efficient terminal differentiation of skeletal myoblasts.

@article{Li2006ERK2IR,
  title={ERK2 is required for efficient terminal differentiation of skeletal myoblasts.},
  author={Jun Li and Sally E Johnson},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={345 4},
  pages={1425-33}
}
Terminal differentiation of skeletal myoblasts involves alignment of the mononucleated cells, fusion into multinucleated syncitia, and transcription of muscle-specific genes. Myogenesis in vivo is regulated partially by IGF-I initiated signaling that results in activation of an intracellular phosphatidylinositol 3 kinase (PI3K) signaling cascade. Downstream signaling through the Raf/MEK/ERK axis, a pathway initiated by IGF-I, also is implicated in the regulation of muscle formation. The… CONTINUE READING