ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal.

  title={ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal.},
  author={Sung-Hyun Kim and Myoung Ok Kim and Yong-Yeon Cho and Ke Yao and Dong Joon Kim and Chul-Ho Jeong and Dong Hoon Yu and Ki Beom Bae and Eun Jin Cho and Sung Keun Jung and Mee Hyun Lee and Hanyong Chen and Jae Young Kim and Ann M. Bode and Ziming Dong},
  journal={Stem cell research},
  volume={13 1},
Nanog regulates human and mouse embryonic stem (ES) cell self-renewal activity. Activation of ERKs signaling negatively regulates ES cell self-renewal and induces differentiation, but the mechanisms are not understood. We found that ERK1 binds and phosphorylates Nanog. Activation of MEK/ERKs signaling and phosphorylation of Nanog inhibit Nanog transactivation, inducing ES cell differentiation. Conversely, suppression of MEK/ERKs signaling enhances Nanog transactivation to inhibit ES cell… CONTINUE READING
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