ERK1 activation is required for S-phase onset and cell cycle progression after fertilization in sea urchin embryos.

@article{Philipova2005ERK1AI,
  title={ERK1 activation is required for S-phase onset and cell cycle progression after fertilization in sea urchin embryos.},
  author={Rada Philipova and Jolanta Kisielewska and Pin Lu and Mark Larman and Jun-yong Huang and M. Whitaker},
  journal={Development},
  year={2005},
  volume={132 3},
  pages={
          579-89
        }
}
Fertilization of sea urchin eggs results in a large, transient increase in intracellular free Ca2+ concentration that is responsible for re-initiation of the cell division cycle. We show that activation of ERK1, a Ca2+-dependent MAP kinase response, is required for both DNA synthesis and cell cycle progression after fertilization. We combine experiments on populations of cells with analysis at the single cell level, and develop a proxy assay for DNA synthesis in single embryos, using GFP-PCNA… CONTINUE READING

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