ERK1/2 signaling pathway in the release of VEGF from Müller cells in diabetes.

  title={ERK1/2 signaling pathway in the release of VEGF from M{\"u}ller cells in diabetes.},
  author={Xiaofeng Ye and Hui Ren and Meng Zhang and Zhongcui Sun and Alice Chu Jiang and Gezhi Xu},
  journal={Investigative ophthalmology & visual science},
  volume={53 7},
PURPOSE Diabetic retinopathy (DR) is one of the most serious complications of diabetes and has become a major blinding eye disease, but its treatment remains unsatisfactory. The ERK1/2 signaling pathway has been shown to participate in regulating secretion of VEGF in DR from our previous studies. The role of VEGF in the development of DR provides a target for treatment. Our present research focuses on Müller cells, a major source of VEGF secretion, to investigate the role of ERK1/2 signaling… CONTINUE READING
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