ERK1/2 signaling is required for the initiation but not progression of TGFβ-induced lens epithelial to mesenchymal transition (EMT).

@article{Wojciechowski2017ERK12SI,
  title={ERK1/2 signaling is required for the initiation but not progression of TGFβ-induced lens epithelial to mesenchymal transition (EMT).},
  author={Magdalena C. Wojciechowski and Leila Mahmutovic and Daisy Yao Shu and Frank J. Lovicu},
  journal={Experimental eye research},
  year={2017},
  volume={159},
  pages={98-113}
}
Transforming Growth Factor Beta (TGFβ) potently induces lens epithelial to mesenchymal transition (EMT). The resultant mesenchymal cells resemble those found in plaques of human forms of subcapsular cataract. Smad signaling has long been implicated as the sole driving force of TGFβ-mediated activity. Rat lens epithelial explants were used to examine the role of the Smad-independent signaling, namely the MAPK/ERK1/2 signaling pathway, in the initiation and progression of TGFβ-induced EMT. Phase… CONTINUE READING
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