ERK1/2 regulation of CD44 modulates oral cancer aggressiveness.

  title={ERK1/2 regulation of CD44 modulates oral cancer aggressiveness.},
  author={Nancy P. Judd and Ashley E. Winkler and Oihana Murillo-Sauca and Joshua J. Brotman and Jonathan H Law and James S Lewis and Gavin P Dunn and Jack D Bui and John B Sunwoo and Ravindra Uppaluri},
  journal={Cancer research},
  volume={72 1},
Carcinogen-induced oral cavity squamous cell carcinoma (OSCC) incurs significant morbidity and mortality and constitutes a global health challenge. To gain further insight into this disease, we generated cell line models from 7,12-dimethylbenz(a)anthracene-induced murine primary OSCC capable of tumor formation upon transplantation into immunocompetent wild-type mice. Whereas several cell lines grew rapidly and were capable of metastasis, some grew slowly and did not metastasize. Aggressively… CONTINUE READING
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Decreased expression of CD80 is a marker for increased tumorigenicity in a new ERK1/2 Controls Mouse Oral Cancer Growth via CD44 Cancer Res

  • ThomasGR, Z Chen, MN Oechsli, FJ Hendler, VanWaesC
  • Int J Cancer
  • 2012
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