ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).

@article{Carrire2011ERK12PR,
  title={ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).},
  author={A. Carri{\`e}re and Yves Romeo and Hugo A. Acosta-Jaquez and Julie Moreau and {\'E}ric Bonneil and Pierre Thibault and Diane C Fingar and Philippe P Roux},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 1},
  pages={567-77}
}
The Ras/mitogen-activated protein kinase (MAPK) pathway regulates a variety of cellular processes by activating specific transcriptional and translational programs. Ras/MAPK signaling promotes mRNA translation and protein synthesis, but the exact molecular mechanisms underlying this regulation remain poorly understood. Increasing evidence suggests that the mammalian target of rapamycin (mTOR) plays an essential role in this process. Here, we show that Raptor, an essential scaffolding protein of… CONTINUE READING
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