ERK1/2 is highly phosphorylated in melanoma metastases and protects melanoma cells from cisplatin-mediated apoptosis.

@article{Mirmohammadsadegh2007ERK12IH,
  title={ERK1/2 is highly phosphorylated in melanoma metastases and protects melanoma cells from cisplatin-mediated apoptosis.},
  author={Alireza Mirmohammadsadegh and Rodrigo Mota and Annett Gustrau and Mohammed Saied Hassan and Sandeep Nambiar and Alessandra Marini and Hans Bojar and Andrea Tannapfel and Ulrich R. Hengge},
  journal={The Journal of investigative dermatology},
  year={2007},
  volume={127 9},
  pages={2207-15}
}
Activation (phosphorylation) of mitogen-activated protein kinase (MAPK) signal transduction through BRAF and RAS causes a variety of functional effects including cell survival and cell death. In this study, we observed high extracellular signal-regulated kinase (ERK)1/2 phosphorylation levels in clinical melanoma metastases and various melanoma cell lines. Treatment of melanoma cell lines with cisplatin, a potent antitumor agent, increased the level of phosphorylated-ERK (P-ERK)1/2 and enhanced… CONTINUE READING

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