ERK1/2-driven and MKP-mediated inhibition of EGF-induced ERK5 signaling in human proximal tubular cells.

@article{Srkzi2007ERK12drivenAM,
  title={ERK1/2-driven and MKP-mediated inhibition of EGF-induced ERK5 signaling in human proximal tubular cells.},
  author={Rita S{\'a}rk{\"o}zi and Bradley M. Miller and Verena Pollack and Elisabeth Feifel and Gert Mayer and Andrey Sorokin and Herbert Schramek},
  journal={Journal of cellular physiology},
  year={2007},
  volume={211 1},
  pages={88-100}
}
The MEK1-ERK1/2 signaling pathway has been implicated in the regulation of renal epithelial cell proliferation, epithelial-to-mesenchymal transition and the induction of an invasive cell phenotype. Much less information is available about the MEK5-ERK5 module and its role in renal epithelial cell proliferation and differentiation. In the present study we have investigated the regulation of these two families of extracellular signal-regulated kinases in epidermal growth factor (EGF)-stimulated… CONTINUE READING