ERK1/2 and Egr-1 contribute to increased TNF-alpha production in rat Kupffer cells after chronic ethanol feeding.

@article{Kishore2002ERK12AE,
  title={ERK1/2 and Egr-1 contribute to increased TNF-alpha production in rat Kupffer cells after chronic ethanol feeding.},
  author={Raj Kishore and J. Rutherford Hill and Megan R. McMullen and Julia Frenkel and Laura E Nagy},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2002},
  volume={282 1},
  pages={
          G6-15
        }
}
Activation of Kupffer cells by lipopolysaccharide (LPS) is a critical step in the pathogenesis of alcoholic liver disease. Kupffer cells isolated from rats fed ethanol in their diet for 4 wk accumulated 4.3-fold more tumor necrosis factor (TNF)-alpha in response to LPS compared with pair-fed rats. In contrast, LPS-stimulated interleukin (IL)-1 accumulation was 50% lower after ethanol feeding. LPS-stimulated TNF-alpha mRNA accumulation was twofold higher after ethanol feeding, whereas IL-1beta… CONTINUE READING

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