ERK1/2-activated de novo Mapkapk2 synthesis is essential for osteogenic growth peptide mitogenic signaling in osteoblastic cells.

@article{Miguel2005ERK12activatedDN,
  title={ERK1/2-activated de novo Mapkapk2 synthesis is essential for osteogenic growth peptide mitogenic signaling in osteoblastic cells.},
  author={Symone M San Miguel and Malka Namdar-Attar and Tommy Noh and Baruch Frenkel and Itai A. Bab},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 45},
  pages={37495-502}
}
In osteoblasts, the mitogen-activated protein kinases ERK1/2 and p38 as well as the cAMP-response element-binding protein (CREB) have been implicated in the regulation of proliferation and differentiation. The osteogenic growth peptide (OGP) is a 14-mer bone cell mitogen that increases bone formation and trabecular bone density and stimulates fracture healing. OGP-(10-14) is the physiologically active form of OGP. Using gene array analysis, real-time reverse transcription-PCR, and immunoblot… CONTINUE READING
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