ERK signaling, but not c-Raf, is required for gonadotropin-releasing hormone (GnRH)-induced regulation of Nur77 in pituitary gonadotropes.

@article{Bliss2012ERKSB,
  title={ERK signaling, but not c-Raf, is required for gonadotropin-releasing hormone (GnRH)-induced regulation of Nur77 in pituitary gonadotropes.},
  author={Stuart P. Bliss and Amy M. Navratil and Jianjun Xie and Andrew J Miller and Manuela Baccarini and Mark S Roberson},
  journal={Endocrinology},
  year={2012},
  volume={153 2},
  pages={700-11}
}
Stimulation of pituitary gonadotropes by hypothalamic GnRH leads to the rapid expression of several immediate early genes that play key roles in orchestrating the response of the gonadotrope to hypothalamic stimuli. Elucidation of the signaling mechanisms that couple the GnRH receptor to this immediate early gene repertoire is critical for understanding the molecular basis of GnRH action. Here we identify signaling mechanisms that underlie regulation of the orphan nuclear receptor Nur77 as a… CONTINUE READING