ERK phosphorylation is linked to VEGFR2 expression and Ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis

@article{Svensson2005ERKPI,
  title={ERK phosphorylation is linked to VEGFR2 expression and Ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis},
  author={Sofie Svensson and Karin Jirstr{\"o}m and Lisa Ryd{\'e}n and G{\"o}ran Roos and Stefan O. Emdin and Michael C. Ostrowski and G{\"o}ran Landberg},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={4370-4379}
}
Extracellular signal-regulated kinase (ERK)1/2 signalling mediates communication between growth factor receptors and the cell nucleus and has been linked to several key events in the transformation process such as proliferation and invasion. We therefore sought to delineate the degree of phosphorylated ERK1/2 in breast cancer and potential links to upstream receptors such as VEGFR2, ErbB2, downstream targets, such as Ets-2, as well as clinico-pathological parameters, clinical outcome and… CONTINUE READING

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