ERK pathway activation is required for amyloid-β(1-40)(-)induced neurotoxicity of THP-1 human monocytes towards SK-N-SH neuroblastoma.

Abstract

Alzheimer's disease (AD) is characterized by amyloid-β peptide deposition, increased activated microglia, and progressive loss of neurons in the brain. Although Aβ₁₋₄₀ can elicit inflammation in microglia, the intracellular signaling events mediating these effects are poorly defined. Here we show that cell-free supernatant from Aβ₁₋₄₀-treated THP-1… (More)
DOI: 10.1016/j.brainres.2011.01.013

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Cite this paper

@article{Yin2011ERKPA, title={ERK pathway activation is required for amyloid-β(1-40)(-)induced neurotoxicity of THP-1 human monocytes towards SK-N-SH neuroblastoma.}, author={Lin-lin Yin and Wei Li and Yan-Qi Chu and Lin Li}, journal={Brain research}, year={2011}, volume={1378}, pages={9-17} }