ERK dimers and scaffold proteins: unexpected partners for a forgotten (cytoplasmic) task.

@article{Casar2009ERKDA,
  title={ERK dimers and scaffold proteins: unexpected partners for a forgotten (cytoplasmic) task.},
  author={Berta Casar and Ad{\'a}n Pinto and Piero Crespo},
  journal={Cell cycle},
  year={2009},
  volume={8 7},
  pages={1007-13}
}
Signals transmitted by ERK1/2 MAP Kinases regulate the functions of multiple substrates present in the nucleus and in the cytoplasm, in similar proportions. In spite of this fact, the prevailing trend of the field has been to focus on the nuclear component, being considered the main executor of ERK biological functions. Following this fashion, scaffold proteins have been often described as modulators of ERK phosphorylation in their route, either as monomers or as dimers, to their ultimate… CONTINUE READING

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