ERK differentially regulates Th17- and Treg-cell development and contributes to the pathogenesis of colitis.

@article{Liu2013ERKDR,
  title={ERK differentially regulates Th17- and Treg-cell development and contributes to the pathogenesis of colitis.},
  author={Houpu Liu and Suxia Yao and Sara M. Dann and Hongwei Qin and Charles O Elson and Yingzi Cong},
  journal={European journal of immunology},
  year={2013},
  volume={43 7},
  pages={1716-26}
}
Although the development of T-cell subsets is mainly regulated by a master transcriptional regulator and phosphorylation of the STAT protein in response to distinct cytokine stimulation, accumulating data indicate that other signaling pathways are also involved in regulating or fine-tuning T-cell lineage commitment. In this report, we investigated the role of ERK, mitogen-activated protein kinase (MAPK), in Th17 and Treg cell development. We demonstrate that blockade of ERK activation inhibited… CONTINUE READING

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