ERK-dependent induction of TNFalpha expression by the environmental contaminant benzo(a)pyrene in primary human macrophages.

@article{Lecureur2005ERKdependentIO,
  title={ERK-dependent induction of TNFalpha expression by the environmental contaminant benzo(a)pyrene in primary human macrophages.},
  author={Val{\'e}rie Lecureur and Eric Le Ferrec and Monique N'diaye and Marc Le Vee and Claire Gardyn and David Gilot and Olivier Fardel},
  journal={FEBS letters},
  year={2005},
  volume={579 9},
  pages={
          1904-10
        }
}
Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BP) are toxic environmental contaminants known to enhance production of pro-inflammatory cytokines such as IL-1beta. The present study was designed in order to determine whether TNFalpha, another cytokine acting in inflammation, may also constitute a target for these chemicals. Both TNFalpha mRNA and TNFalpha secretion levels were found to be enhanced in human BP-treated macrophages. Dioxin, a contaminant activating the aryl… CONTINUE READING

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