ERK and p38 MAPK signaling pathways negatively regulate CIITA gene expression in dendritic cells and macrophages.

@article{Yao2006ERKAP,
  title={ERK and p38 MAPK signaling pathways negatively regulate CIITA gene expression in dendritic cells and macrophages.},
  author={Yongxue Yao and Qi Xu and Myung-Ja Kwon and R. A. Da Matta and Yusen Liu and S U Hong and Cheong-Hee Chang},
  journal={Journal of immunology},
  year={2006},
  volume={177 1},
  pages={70-6}
}
The CIITA is a master regulator for MHC class II expression, but the signaling events that control CIITA expression remain poorly understood. In this study, we report that both constitutive and IFN-gamma-inducible expression of CIITA in mouse bone marrow-derived dendritic cells (DC) and macrophages, respectively, are regulated by MAPK signals. In DC, the inhibitory effect of LPS on CIITA expression was prevented by MyD88 deficiency or pharmacological MAPK inhibitors specific for MEK (U0126) and… CONTINUE READING