ERK and calcium in activation of HIF-1.

  title={ERK and calcium in activation of HIF-1.},
  author={Denis Mottet and Gaetan Michel and Patricia Renard and Noelle Ninane and Martine Raes and Carine Michiels},
  journal={Annals of the New York Academy of Sciences},
HIF-1 (hypoxia-inducible factor-1) is the main transcription factor responsible for increased gene expression in hypoxia. The oxygen-dependent regulation of HIF-1 activity occurs at multiple levels in vivo. The mechanisms regulating HIF-1alpha protein expression have been most extensively analyzed, but the ones modulating HIF-1 transcriptional activity remain unclear. Changes in the phosphorylation and/or redox status of HIF-1alpha certainly play a role. Here, we show that ionomycin could… CONTINUE READING
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