ERK and beyond: insights from B-Raf and Raf-1 conditional knockouts.

  title={ERK and beyond: insights from B-Raf and Raf-1 conditional knockouts.},
  author={Gergana Galabova-Kovacs and Andrea Kolbus and Dana Matzen and Katrin Meissl and Daniela Piazzolla and Cristina Rubiolo and Katharina N. Steinitz and Manuela Baccarini},
  journal={Cell cycle},
  volume={5 14},
The Raf/MEK/ERK cascade is a highly conserved signal transduction module whose activation reportedly results in a plethora of physiological outcomes. Depending on the cell type or the stimulus used, the pathway has been implicated in proliferation, differentiation, survival, and migration. Their wide range of activities renders the component of the Raf/MEK/ERK pathway prime candidates for molecule-targeted therapies, in particular, but not exclusively, in the context of cancer. Ras, Raf and MEK… CONTINUE READING
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