ERK activation contributes to regulation of spontaneous contractile tone via superoxide anion in isolated rat aorta of angiotensin II-induced hypertension.

@article{Ding2007ERKAC,
  title={ERK activation contributes to regulation of spontaneous contractile tone via superoxide anion in isolated rat aorta of angiotensin II-induced hypertension.},
  author={Lili Ding and Alexander Chapman and Ryan Boyd and Hui Di Wang},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={292 6},
  pages={
          H2997-3005
        }
}
Arteries from hypertensive animals and humans have increased spontaneous tone. Increased superoxide anion (superoxide) contributes to elevated blood pressure (BP) and spontaneous tone in hypertension. The association between the extracellular signaling-regulated kinase 1/2 (ERK1/2)-mitogen-activated protein kinase (MAPK) signaling pathway and generation of superoxide and spontaneous tone in isolated aorta was studied in angiotensin II (ANG II)-infused hypertensive (HT) rats. Systolic BP… CONTINUE READING

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