ERK activation by thymosin-beta-4 (TB4) overexpression induces paclitaxel-resistance.

Abstract

The development of paclitaxel-resistance in tumors is one of the most significant obstacles to successful therapy. Thymosin-beta-4 (TB4) has been known as actin-sequestering protein and functions in tumor metastasis. Here, we overexpressed TB4 in HeLa cells (TB4-HeLa) and examined the effect of TB4 in paclitaxel-induced cell death. TB4-HeLa cells showed a… (More)

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Cite this paper

@article{Oh2006ERKAB, title={ERK activation by thymosin-beta-4 (TB4) overexpression induces paclitaxel-resistance.}, author={Su-Young Oh and Ji-Hee Song and J Gil and Jeong-Hee Kim and Y K Yeom and Eun-Yi Moon}, journal={Experimental cell research}, year={2006}, volume={312 9}, pages={1651-7} }