ERK MAPK activation mediates the antiapoptotic signaling of melatonin in UVB-stressed U937 cells.

Abstract

The pineal gland hormone melatonin has been recently described to downregulate the intrinsic (or damage-induced) pathway of apoptosis in human leukocytes. These properties appear to depend on a specific mitochondrial signaling of melatonin which is associated with a lower generation of reactive oxygen species and a better control of redox-sensitive… (More)
DOI: 10.1016/j.freeradbiomed.2008.09.017

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