ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization.

@article{Sun2009ERISAE,
  title={ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization.},
  author={Wenxiang Sun and Yang Li and Lu Chen and Huihui Chen and Fuping You and Xiang Zhou and Yi Zhou and Zhonghe Zhai and Danying Chen and Zhengfan Jiang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 21},
  pages={8653-8}
}
We report here the identification and characterization of a protein, ERIS, an endoplasmic reticulum (ER) IFN stimulator, which is a strong type I IFN stimulator and plays a pivotal role in response to both non-self-cytosolic RNA and dsDNA. ERIS (also known as STING or MITA) resided exclusively on ER membrane. The ER retention/retrieval sequence RIR was found to be critical to retain the protein on ER membrane and to maintain its integrity. ERIS was dimerized on innate immune challenges… CONTINUE READING
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