ERG and PTEN status of isolated high-grade PIN occurring in cystoprostatectomy specimens without invasive prostatic adenocarcinoma.

@article{Morais2016ERGAP,
  title={ERG and PTEN status of isolated high-grade PIN occurring in cystoprostatectomy specimens without invasive prostatic adenocarcinoma.},
  author={Carlos L. Morais and Liana B. Guedes and Jessica Hicks and Alexander S. Baras and Angelo M. De Marzo and Tamara L. Lotan},
  journal={Human pathology},
  year={2016},
  volume={55},
  pages={
          117-25
        }
}
High-grade prostatic intraepithelial neoplasia (HGPIN) is widely believed to represent a precursor to invasive prostatic adenocarcinoma. However, recent molecular studies have suggested that retrograde spread of invasive adenocarcinoma into pre-existing prostatic ducts can morphologically mimic HGPIN. Thus, previous molecular studies characterizing morphologically identified HGPIN occurring in radical prostatectomies or needle biopsies with concurrent invasive carcinoma may be partially… CONTINUE READING

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