ERCC1 is required for FANCD2 focus formation.

@article{McCabe2008ERCC1IR,
  title={ERCC1 is required for FANCD2 focus formation.},
  author={Kevin M. McCabe and Aaron Hemphill and Yassmine M N Akkari and Petra M. Jakobs and Daniel Pauw and Susan B. Olson and R. E. Moses and Markus Grompe},
  journal={Molecular genetics and metabolism},
  year={2008},
  volume={95 1-2},
  pages={66-73}
}
The rare genetic disorder Fanconi anemia, caused by a deficiency in any of at least thirteen identified genes, is characterized by cellular sensitivity to DNA interstrand crosslinks and genome instability. The excision repair cross complementing protein, ERCC1, first identified as a participant in nucleotide excision repair, appears to also act in crosslink repair, possibly in incision and at a later stage. We have investigated the relationship of ERCC1 to the Fanconi anemia pathway, using… CONTINUE READING

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