ERCC1: a comparative genomic perspective.

  title={ERCC1: a comparative genomic perspective.},
  author={Michael David Wilson and Cindy C Ruttan and Ben F. Koop and Barry W. Glickman},
  journal={Environmental and molecular mutagenesis},
  volume={38 2-3},
ERCC1 plays an essential role in the nucleotide excision repair (NER) of DNA. We compare 37 kb of sequence from the ERCC1 region on human chromosome 19q13.3 to the orthologous region on mouse chromosome 7. In addition to showing the conserved gene structure between ERCC1, ASE-1, and their murine counterparts, this genomic comparison reveals a highly conserved 497 bp segment found 5 kb upstream of ERCC1 exon 1 that contains a CpG island and previously unidentified "classical" promoter elements… CONTINUE READING
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