ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.

@article{Zhu2003ERCC1XPFRT,
  title={ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.},
  author={Xu-Dong Zhu and Laura J. Niedernhofer and Bernhard Kuster and Matthias Mann and Jan H. J. Hoeijmakers and Titia de Lange},
  journal={Molecular cell},
  year={2003},
  volume={12 6},
  pages={
          1489-98
        }
}
Human telomeres are protected by TRF2. Inhibition of this telomeric protein results in partial loss of the telomeric 3' overhang and chromosome end fusions formed through nonhomologous end-joining (NHEJ). Here we report that ERCC1/XPF-deficient cells retained the telomeric overhang after TRF2 inhibition, identifying this nucleotide excision repair endonuclease as the culprit in overhang removal. Furthermore, these cells did not accumulate telomere fusions, suggesting that overhang processing is… CONTINUE READING
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