ERBB3 (HER3) is a key sensor in the regulation of ERBB-mediated signaling in both low and high ERBB2 (HER2) expressing cancer cells

Abstract

Aberrant expression and activation of EGFR and ERBB2 (HER2) have been successfully targeted for cancer therapeutics. Recent evidence from both basic and clinical studies suggests that ERBB3 (HER3) serves as a key activator of downstream signaling through dimerization with other ERBB proteins and plays a critical role in the widespread clinical resistance to… (More)
DOI: 10.1002/cam4.10

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Cite this paper

@inproceedings{Choi2012ERBB3I, title={ERBB3 (HER3) is a key sensor in the regulation of ERBB-mediated signaling in both low and high ERBB2 (HER2) expressing cancer cells}, author={Byung-Kwon Choi and Xuejun Fan and Hui Deng and Ningyan Zhang and Zhiqiang An}, booktitle={Cancer medicine}, year={2012} }