ERBB2 induces an antiapoptotic expression pattern of Bcl-2 family members in node-negative breast cancer.

@article{Petry2010ERBB2IA,
  title={ERBB2 induces an antiapoptotic expression pattern of Bcl-2 family members in node-negative breast cancer.},
  author={Ilka Brigitte Petry and Esther Fieber and Maximilian Schmidt and Mathias Gehrmann and Susanne Gebhard and Matthias Hermes and Wiebke Schormann and Silvia Selinski and Evgenia Freis and Holger Schwender and Marc Brulport and Katja Ickstadt and J{\"o}rg Rahnenf{\"u}hrer and Lindsey J. Maccoux and Jonathan West and Heinz Koelbl and Martin Schuler and Jan G. Hengstler},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2010},
  volume={16 2},
  pages={
          451-60
        }
}
PURPOSE Members of the Bcl-2 family act as master regulators of mitochondrial homeostasis and apoptosis. We analyzed whether ERBB2 influences the prognosis of breast cancer by influencing the proapoptotic versus antiapoptotic balance of Bcl-2 family members. EXPERIMENTAL DESIGN ERBB2-regulated Bcl-2 family members were identified by inducible expression of ERBB2 in MCF-7 breast cancer cells and by correlation analysis with ERBB2 expression in breast carcinomas. The prognostic relevance of… CONTINUE READING
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