ERBB2 (HER2/neu) oncogene is frequently amplified in squamous cell carcinoma of the uterine cervix.

@article{Mitra1994ERBB2O,
  title={ERBB2 (HER2/neu) oncogene is frequently amplified in squamous cell carcinoma of the uterine cervix.},
  author={Ardhendu Bikash Mitra and V. V. S. Murty and Mahendra Pratap and Pushpa Sodhani and Raju S. K. Chaganti},
  journal={Cancer research},
  year={1994},
  volume={54 3},
  pages={637-9}
}
We evaluated a panel of 22 protooncogenes for amplification in 50 primary, untreated squamous cell carcinomas of the uterine cervix. The tumors studied belonged to clinical stages II and III; histologically, the majority of them were moderately to well differentiated. Amplification represented by 5 or more copies was observed for the genes MYCL1, SEA, CCND1, BCL1, and GLI in one case each (2%); HRAS in 2 cases (4%); and ERBB2 in 7 cases (14%). Amplification of ERBB2 ranged from 5 to 68 copies… CONTINUE READING

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