ERAP1 polymorphisms and haplotypes are associated with ankylosing spondylitis susceptibility and functional severity in a Spanish population.

@article{Szczypiorska2011ERAP1PA,
  title={ERAP1 polymorphisms and haplotypes are associated with ankylosing spondylitis susceptibility and functional severity in a Spanish population.},
  author={Magdalena Szczypiorska and Alejandra Sanchez and Nerea Guti{\'e}rrez Bartolom{\'e} and David Arteta and J. S{\'a}nchez Sanz and Elia Brito and Pilar Berrocal Fern{\'a}ndez and E Est{\'e}vez Collantes and Antonio Mart{\'i}nez and Diego Tejedor and Marta Artieda and Juan Bartolome Mulero},
  journal={Rheumatology},
  year={2011},
  volume={50 11},
  pages={
          1969-75
        }
}
OBJECTIVES The aim of this study was to assess the involvement of the endoplasmic reticulum aminopeptidase 1 (ERAP1) gene in AS susceptibility and functional severity in a Spanish population. METHODS Eight single nucleotide polymorphisms (SNPs) spanning the ERAP1 gene were genotyped by allele-specific fluorescent PCR in 300 AS Spanish patients and 300 spondylarthritis-free controls. The influence of the ERAP1 SNPs on the functional severity of AS was analysed with the BASFI corrected for… CONTINUE READING
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