ER stress signaling by regulated splicing: IRE1/HAC1/XBP1.

@article{Back2005ERSS,
  title={ER stress signaling by regulated splicing: IRE1/HAC1/XBP1.},
  author={Sung Hoon Back and Martin Schr{\"o}der and Kyungho Lee and Kezhong Zhang and Randal J Kaufman},
  journal={Methods},
  year={2005},
  volume={35 4},
  pages={395-416}
}
The endoplasmic reticulum (ER) serves many specialized functions in the cell including calcium storage and gated release, biosynthesis of membrane and secretory proteins, and production of lipids and sterols. Therefore, the ER integrates many internal and external signals to coordinate downstream responses, although the mechanism(s) that maintain homeostasis are largely unknown. When misfolded or unfolded proteins accumulate in the ER, an intracellular signaling pathway termed the unfolded… CONTINUE READING

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