ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis.

@article{Condamine2014ERSR,
  title={ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis.},
  author={Thomas Condamine and Vinit Kumar and Indu R. Ramachandran and Je-in Youn and Esteban Celis and Niklas K. Finnberg and Wafik S El-Deiry and Rafael Winograd and Robert H. Vonderheide and Nickolas R English and Stella C. Knight and Hideo Yagita and Judith C Mccaffrey and Scott J. Antonia and Neil G Hockstein and R. Witt and Gregory Masters and Thomas O Bauer and Dmitry I Gabrilovich},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 6},
  pages={2626-39}
}
Myeloid-derived suppressor cells (MDSCs) dampen the immune response thorough inhibition of T cell activation and proliferation and often are expanded in pathological conditions. Here, we studied the fate of MDSCs in cancer. Unexpectedly, MDSCs had lower viability and a shorter half-life in tumor-bearing mice compared with neutrophils and monocytes. The reduction of MDSC viability was due to increased apoptosis, which was mediated by increased expression of TNF-related apoptosis-induced ligand… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 56 extracted citations

Similar Papers

Loading similar papers…