ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1.

@article{Shiraishi2006ERSA,
  title={ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1.},
  author={Hiroshi Shiraishi and Hideaki Okamoto and Akihiko Yoshimura and Hiroki Yoshida},
  journal={Journal of cell science},
  year={2006},
  volume={119 Pt 19},
  pages={3958-66}
}
Accumulation of unfolded proteins induces endoplasmic reticulum (ER) stress. Excessive and prolonged stresses lead cells to apoptosis. However, the precise molecular mechanisms of ER stress-induced apoptosis have not been fully elucidated. We investigated the involvement of the apoptosome in ER stress-induced cell death pathway using mouse embryonic fibroblasts (MEFs) and mice deficient for Apaf-1. Apaf-1-deficient MEFs showed more resistance to ER stress-inducing reagents as compared with wild… CONTINUE READING

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