ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation

@article{Kouroku2007ERS,
  title={ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation},
  author={Yoriko Kouroku and Eriko Fujita and Isei Tanida and Takashi Ueno and Atushi Isoai and Hiromichi Kumagai and Satoshi Ogawa and Randal J Kaufman and Eiki Kominami and Takashi Momoi},
  journal={Cell Death and Differentiation},
  year={2007},
  volume={14},
  pages={230-239}
}
Expanded polyglutamine 72 repeat (polyQ72) aggregates induce endoplasmic reticulum (ER) stress-mediated cell death with caspase-12 activation and vesicular formation (autophagy). We examined this relationship and the molecular mechanism of autophagy formation. Rapamycin, a stimulator of autophagy, inhibited the polyQ72-induced cell death with caspase-12 activation. PolyQ72, but not polyQ11, stimulated Atg5-Atg12-Atg16 complex-dependent microtubule-associated protein 1 (MAP1) light chain 3 (LC3… CONTINUE READING
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