ER stress: can the liver cope?

  title={ER stress: can the liver cope?},
  author={Cheng Ji and Neil Kaplowitz},
  journal={Journal of hepatology},
  volume={45 2},
Hepatocytes contain abundant endoplasmic reticulum (ER) which is essential for protein metabolism and stress signaling. Hepatic viral infections, metabolic disorders, mutations of genes encoding ER-resident proteins, and abuse of alcohol or drugs can induce ER stress. Liver cells cope with ER stress by an adaptive protective response termed unfolded protein response (UPR), which includes enhancing protein folding and degradation in the ER and down-regulating overall protein synthesis. When the… CONTINUE READING


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