ER beta: identification and characterization of a novel human estrogen receptor.

@article{Mosselman1996ERBI,
  title={ER beta: identification and characterization of a novel human estrogen receptor.},
  author={Sietse Mosselman and Jan Polman and R. D. Dijkema},
  journal={FEBS letters},
  year={1996},
  volume={392 1},
  pages={49-53}
}
A novel estrogen receptor (hereinafter referred to as ER beta) was cloned using degenerate PCR primers. A comparison of the amino acid sequence of ER beta with the "classical' ER (ER alpha) shows a high degree of conservation of the DNA-binding domain (96%), and of the ligand-binding domain (58%). In contrast, the A/B domain, the hinge region and the F-domain are not conserved. Northern blot analysis revealed that ER beta is expressed in human thymus, spleen, ovary and testis. Transient… CONTINUE READING
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