ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis.

@article{Shi2017ERassociatedDI,
  title={ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis.},
  author={Guojun Shi and Diane RM Somlo and Geun Hyang Kim and Cristina Prescianotto-Baschong and Shengyi Sun and Nicole Beuret and Qiaoming Long and Jonas Rutishauser and Peter Arvan and Martin Spiess and Ling Qi},
  journal={The Journal of clinical investigation},
  year={2017},
  volume={127 10},
  pages={
          3897-3912
        }
}
Peptide hormones are crucial regulators of many aspects of human physiology. Mutations that alter these signaling peptides are associated with physiological imbalances that underlie diseases. However, the conformational maturation of peptide hormone precursors (prohormones) in the ER remains largely unexplored. Here, we report that conformational maturation of proAVP, the precursor for the antidiuretic hormone arginine-vasopressin, within the ER requires the ER-associated degradation (ERAD… CONTINUE READING
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