ER and PR in renomedullary interstitial cells during Syrian hamster estrogen-induced tumorigenesis: evidence for receptor-mediated oncogenesis.

@article{Li2001ERAP,
  title={ER and PR in renomedullary interstitial cells during Syrian hamster estrogen-induced tumorigenesis: evidence for receptor-mediated oncogenesis.},
  author={Jonathan S. Li and Saravut John Weroha and Marilyn F Davis and Ossama Tawfik and Xiaonan Hou and Sara Antonia Li},
  journal={Endocrinology},
  year={2001},
  volume={142 9},
  pages={4006-14}
}
The estrogen-induced and -dependent Syrian hamster renal tumor is the most intensively studied model in estrogen carcinogenesis. Yet, it remains confounding that the kidney of this species behaves as an estrogen target tissue. As both reproductive and urinary systems arise from the same germinal ridge, we propose that some of the germinal cells, normally destined for the uterus, migrate and establish themselves in the renal corticomedullary region in this hamster strain. These ectopically… CONTINUE READING