ER Stress Negatively Modulates the Expression of the miR-199a/214 Cluster to Regulates Tumor Survival and Progression in Human Hepatocellular Cancer

@inproceedings{Duan2012ERSN,
  title={ER Stress Negatively Modulates the Expression of the miR-199a/214 Cluster to Regulates Tumor Survival and Progression in Human Hepatocellular Cancer},
  author={Quanlu Duan and Xingxu Wang and Wei Gong and Li Feng Ni and Chen Chen and Xingxing He and Fuqiong Chen and Lei Yang and Peihua Wang and Dao Wen Wang},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Recent studies have emphasized causative links between microRNAs (miRNAs) deregulation and tumor development. In hepatocellular carcinoma (HCC), more and more miRNAs were identified as diagnostic and prognostic cancer biomarkers, as well as additional therapeutic tools. This study aimed to investigate the functional significance and regulatory mechanism of the miR-199a2/214 cluster in HCC progression. METHODS AND FINDINGS In this study, we showed that miR-214, as well as miR-199a… CONTINUE READING
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